Consistency of associations of systolic and diastolic blood pressure with white matter hyperintensities: A meta-analysis.

ABSTRACT:

Background

White matter hyperintensities are the commonest manifestation of cerebral small vessel disease, associated with stroke, functional impairment, and cognitive decline. They are commonly preceded by hypertension, but the magnitude and clinical importance of this association is unclear.

Aims

Quantify the relationship between blood pressure and white matter hyperintensities across studies.

Methods

PubMed and EMBASE were searched for studies reporting associations between concurrent or historic blood pressure and white matter hyperintensities. Beta coefficients from linear models were extracted, whether standardized, unstandardized, unadjusted or adjusted for age, sex, and cardiovascular risk factors. Beta-coefficients were combined by fixed and random effects me

SUBMITTER: Wilkinson I 

PROVIDER: S-EPMC8864334 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature