Potential for Selection Bias in Studies of the Association of Hormonal Contraception and Chronic Vulvar Pain.

ABSTRACT: Background: Hormonal contraceptive use is common among reproductive-aged women, but research evaluating its etiological relationship to vulvodynia remains mixed. We sought to evaluate this association and examine the potential for bias due to care-seeking behavior. Materials and Methods: We conducted a case-control study of women recruited from a large health care network database from 2008 to 2011. Of 26,455 eligible respondents, 1168 met the case definition for chronic vulvar pain (CVP). We matched each case to three controls by age and used conditional logistic regression to calculate odds ratios (ORs) for prior hormonal contraception (HC) use and CVP, stratifying cases by whether or not they sought care for their vulvar pain. We also simulated the influence

SUBMITTER: Bond JC 

PROVIDER: S-EPMC8864423 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature