CSF proteomic signature predicts progression to Alzheimer's disease dementia.

ABSTRACT:

Introduction

Individuals in the Alzheimer's disease (AD) continuum with mild cognitive impairment (prodromal AD) are at increased risk to develop dementia. Still, underlying pathophysiological processes remain unclear. We studied whether cerebrospinal fluid (CSF) proteome changes are related to time to clinical progression in prodromal AD.

Methods

We measured 671 CSF proteins in 49 prodromal AD individuals (67±7 years old, 22 [45%] female) from the Amsterdam Dementia Cohort. Associations of protein levels with time to dementia onset were tested with Cox regression models, followed by biological pathway enrichment analysis.

Results

Eighteen (36%) individuals developed dementia during follow-up. In total, 128 (98%) proteins were associated with a 1.4- to 17-fold increas

SUBMITTER: Vromen EM 

PROVIDER: S-EPMC8864445 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature