Adult pancreatic islet endocrine cells emerge as fetal hormone-expressing cells.

ABSTRACT: The precise developmental dynamics of the pancreatic islet endocrine cell types, and their interrelation, are unknown. Some authors claim the persistence of islet cell differentiation from precursor cells after birth ("neogenesis"). Here, using four conditional cell lineage tracing ("pulse-and-chase") murine models, we describe the natural history of pancreatic islet cells, once they express a hormone gene, until late in life. Concerning the contribution of early-appearing embryonic hormone-expressing cells to the formation of islets, we report that adult islet cells emerge from embryonic hormone-expressing cells arising at different time points during development, without any evidence of postnatal neogenesis. We observe specific patterns of hormone gene activation and switching during isl

SUBMITTER: Perez-Frances M 

PROVIDER: S-EPMC8864465 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature