Response-Adapted Treatment Following Radiotherapy in Patients With Resectable Locally Advanced Hypopharyngeal Carcinoma.

ABSTRACT:

Importance

Laryngeal preservation strategies for resectable locally advanced hypopharyngeal carcinoma (LAHPC) have been explored. However, the optimal strategy remains unclear.

Objective

To evaluate a response-adapted strategy based on an early response to radiotherapy (RT) in patients with resectable LAHPC.

Design, setting, and participants

This cohort study was conducted from May 2009 to October 2019 with a median (IQR) follow-up period of 66.5 (44.7-97.0) months. The study was conducted at a tertiary academic medical center and included 423 patients pathologically confirmed stage III and IVB LAHPC. A total of 250 patients with previous cancer history, synchronous primary cancer, stage I or II, or with unresectable hypopharyngeal carcinoma were excluded.

Exposure

SUBMITTER: Luo X 

PROVIDER: S-EPMC8864511 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature