Lack of association between bridging integrator 1 (BIN1) rs744373 polymorphism and tau-PET load in cognitively intact older adults.

ABSTRACT:

Introduction

The bridging integrator 1(BIN1) rs744373 risk polymorphism has been linked to increased [¹⁸F]AV1451 signal in non-demented older adults (ie., mild cognitive impairment [MCI] plus cognitively normal [CN] individuals). However, the association of BIN1 with in vivo tau, amyloid beta (Aβ) burden, and cognitive impairment in the asymptomatic stage of Alzheimer's disease (AD) remains unknown.

Methods

The BIN1 effect on [¹⁸F]AV1451 binding was evaluated in 59 cognitively normal (CN) participants (39% apolipoprotein E [APOE ε4]) from the Flemish Prevent AD Cohort KU Leuven (F-PACK), as well as in 66 Alzheimer's Disease Neuroimaging Initiative (ADNI) CN participants, using voxelwise and regional statistics. For comparison

SUBMITTER: Schaeverbeke J 

PROVIDER: S-EPMC8864573 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature