Association of fatigue, inflammation, and physical activity on gait speed: the Long Life Family Study.

ABSTRACT:

Background

Fatigue, inflammation, and physical activity (PA) are all independently associated with gait speed, but their directionality is not fully elucidated.

Aims

Evaluate the bidirectional associations amongst fatigue, inflammation, and PA on gait speed.

Methods

This cross sectional study included probands (n = 1280, aged 49-105) and offspring (n = 2772, aged 24-88) in the Long Life Family Study. We assessed gait speed, fatigue with the question "I could not get going", inflammation using fasting interleukin-6 (IL-6) and high sensitivity C-reactive protein (CRP), and self-reported PA as walking frequency in the past two weeks. The two generations were examined separately using linear mixed modeling.

Results

Lower fatigue, lower IL-6, and greater PA were all

SUBMITTER: Renner SW 

PROVIDER: S-EPMC8864668 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature