Cardiovascular Disease Risk Factors and Metabolic Morbidity in a Longitudinal Study of Congenital Adrenal Hyperplasia.

ABSTRACT:

Context

Patients with congenital adrenal hyperplasia (CAH) are exposed to hyperandrogenism and supraphysiologic glucocorticoids, both of which can increase risk of metabolic morbidity.

Objective

Our aim was to evaluate cardiovascular and metabolic morbidity risk in a longitudinal study of patients with CAH spanning both childhood and adulthood.

Design and setting

Patients with classic CAH followed for a minimum of 5 years during both childhood and adulthood (n = 57) at the National Institutes of Health were included and compared with the US general population using NHANES data.

Main outcome measures

Obesity, hypertension, insulin resistance, fasting hyperglycemia, and dyslipidemia.

Results

Compared to the US population, patients with CAH had higher (P < 

SUBMITTER: Torky A 

PROVIDER: S-EPMC8864751 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature