Associations between adipokines gene polymorphisms and knee osteoarthritis: a meta-analysis.

ABSTRACT:

Background

Adipokines gene polymorphisms are speculated to be associated with the risk of knee osteoarthritis (OA), but evidence remains conflicting. This study therefore aimed to examine whether associations exist between adipokines gene polymorphisms and knee OA by considering the evidence collected from eligible studies through a meta-analysis.

Methods

A systematic search was performed on PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), and Wanfang up to March 31, 2020. Meta-analysis was carried out by focusing on the associations between adipokines gene polymorphisms and knee OA with the allele model, dominant model, and recessive model.

Results

The present meta-analysis included 5 eligible studies for ADIPOQ rs1501299 with 1,021 cas

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8864815 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature