Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease.
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ABSTRACT:
SUBMITTER: Vrba L
PROVIDER: S-EPMC8864826 | biostudies-literature | 2022 Feb
REPOSITORIES: biostudies-literature
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Liquid biopsy, using a novel DNA methylation signature, distinguishes pancreatic adenocarcinoma from benign pancreatic disease.
Vrba Lukas L Futscher Bernard W BW Oshiro Marc M Watts George S GS Menashi Emmanuel E Hu Charles C Hammad Hytham H Pennington Daniel R DR Golconda Umamaheshwari U Gavini Hemanth H Roe Denise J DJ Shroff Rachna T RT Nelson Mark A MA
Clinical epigenetics 20220222 1
We tested the ability of a novel DNA methylation biomarker set to distinguish metastatic pancreatic cancer cases from benign pancreatic cyst patients and to monitor tumor dynamics using quantitative DNA methylation analysis of cell-free DNA (cfDNA) from blood samples. The biomarkers were able to distinguish malignant cases from benign disease with high sensitivity and specificity (AUC = 0.999). Furthermore, the biomarkers detected a consistent decline in tumor-derived cfDNA in samples from patie ...[more]
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