Carrier-free multifunctional nanomedicine for intraperitoneal disseminated ovarian cancer therapy.

ABSTRACT:

Background

Ovarian cancer is the most lethal gynecological cancer which is characterized by extensive peritoneal implantation metastasis and malignant ascites. Despite advances in diagnosis and treatment in recent years, the five-year survival rate is only 25-30%. Therefore, developing multifunctional nanomedicine with abilities of promoting apoptosis and inhibiting migration on tumor cells would be a promising strategy to improve the antitumor effect.

Methods and results

In this study, we developed a novel ACaT nanomedicine composed of alendronate, calcium ions and cyclin-dependent kinase 7 (CDK7) inhibitor THZ1. With the average size of 164 nm and zeta potential of 12.4 mV, the spherical ACaT nanoparticles were selectively internalized by tumor cells and effectively accumu

SUBMITTER: Huang X 

PROVIDER: S-EPMC8864853 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature