Synthesis, in vitro biological evaluation and molecular modelling of new 2-chloro-3-hydrazinopyrazine derivatives as potent acetylcholinesterase inhibitors‏ on PC12 cells.

ABSTRACT:

Background

The loss of cholinergic neurotransmission in Alzheimer's disease (AD) patients' brain is accompanied by a reduced concentration of Acetylcholine (ACh) within synaptic clefts. Thus, the use of acetylcholinesterase inhibitors (AChEIs) to block the cholinergic degradation of ACh is a promising approach for AD treatment. In the present study, a series of 2-chloro-3-hydrazinopyrazine derivatives (CHP1-5) were designed, synthesized, and biologically evaluated as potential multifunctional anti-AD agents.

Methods

In addition, the chemical structures and purity of the synthesized compounds were elucidated through using IR, ¹H and ¹³C NMR, and elemental analyses. Further, the intended compounds were assessed in vitro for their AChE inhibitory and neuro

SUBMITTER: Taheri M 

PROVIDER: S-EPMC8864858 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature