Mesenchymal Mycn participates in odontoblastic lineage commitment by regulating Kruppel-like Factor 4 (Klf4) in mice.

ABSTRACT:

Background

Commitment of mouse dental papilla cells (mDPCs) to the odontoblast lineage is critical for dentin formation, and this biological process is regulated by a complex transcription factor network. The transcription factor Mycn is a proto-oncogene that plays an important role in tumorigenesis and normal embryonic development. An early study revealed that Mycn is exclusively expressed in dental mesenchymal cells at E15.5, which implies a potential role of Mycn in dentinogenesis. However, the role of Mycn in dentin formation remains elusive. Thus, it is of considerable interest to elucidate the role of Mycn in dentin formation.

Methods

Mycn^fl/fl; Osr2^IresCre (Mycn^Osr2) and Mycn^fl/fl; K14^Cre (Mycn^K14) tran

SUBMITTER: Huang Z 

PROVIDER: S-EPMC8864903 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature