Mapping Proteome Changes in Microsatellite Stable, Recurrent Colon Cancer Reveals a Significant Immune System Signature.

ABSTRACT:

Background/aim

Better stratification of the risk of relapse will help select the right patients for adjuvant treatment and improve targeted therapies for patients with colon cancer.

Materials and methods

To understand why a subset of tumors relapse, we compared the proteome of two groups of patients with colon cancer with similar stage, stratified based on the presence or absence of recurrence.

Results

Using tumor biopsies from the primary operation, we identified dissimilarity between recurrent and nonrecurrent mismatch satellite stable colon cancer and found that signaling related to immune activation and inflammation was associated with relapse.

Conclusion

Immune modulation may have an effect on mismatch satellite stable colon cancer. At present, immune ther

SUBMITTER: Berle M 

PROVIDER: S-EPMC8865039 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature