Down-regulation of TRPV6 Is Associated With Adverse Prognosis in Hepatocellular Carcinoma Treated With Curative Resection.

ABSTRACT:

Background/aim

Transient receptor potential vanilloid 6 (TRPV6), an endothelial Ca²⁺-selective entry channel, is expressed in various cancer types, and a selective TRPV6 inhibitor is currently being investigated in a clinical trial. However, TRPV6 expression in hepatocellular carcinoma (HCC) has not been reported.

Materials and methods

We evaluated TRPV6 expression in 219 cases of HCC and analyzed its association with clinicopathological parameters and prognostic significance. TRPV6 mRNA expression was compared between HCC and non-tumor liver tissues using various public datasets, and its prognostic effect was examined in The Cancer Genome Atlas (TCGA) cohort.

Results

Low TRPV6 expression was found in 37.4% of patients, which was significantly associated wi

SUBMITTER: Koh HH 

PROVIDER: S-EPMC8865045 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature