Effectiveness of olanzapine in the treatment of anorexia nervosa: A systematic review and meta-analysis.

ABSTRACT:

Objective

Anorexia nervosa (AN) is a severe psychiatric disorder characterized by starvation and malnutrition, a high incidence of coexisting psychiatric conditions, and treatment resistance. The effect of pharmacotherapy has been controversial.

Method

A systematic review was conducted for evidence of an effect of olanzapine versus placebo in adults or its effect as adjuvant treatment of AN in adolescents.

Results

A total of seven articles (304 patients with AN) were identified. There were four double-blind, randomized studies examining the effect of olanzapine in the treatment of AN. The mean difference in body mass index (BMI) at the end of treatment between olanzapine and placebo was 0.67 kg/m² (95% confidence interval (CI) 0.15-1.18 kg/m² ; p

SUBMITTER: Han R 

PROVIDER: S-EPMC8865148 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature