Sex-dependent influence of postweaning environmental enrichment in Angelman syndrome model mice.

ABSTRACT:

Introduction

Angelman syndrome (AS) is a rare neurodevelopmental disorder caused by mutation or loss of UBE3A and marked by intellectual disability, ataxia, autism-like symptoms, and other atypical behaviors. One route to treatment may lie in the role that environment plays early in postnatal life. Environmental enrichment (EE) is one manipulation that has shown therapeutic potential in preclinical models of many brain disorders, including neurodevelopmental disorders. Here, we examined whether postweaning EE can rescue behavioral phenotypes in Ube3a maternal deletion mice (AS mice), and whether any improvements are sex-dependent.

Methods

Male and female mice (C57BL/6J Ube3a^tm1Alb mice and wild-type (WT) littermates; ≥10 mice/group) were randomly assigned to stand

SUBMITTER: Cosgrove JA 

PROVIDER: S-EPMC8865162 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature