Effect of Stromal Vascular Fractions on Angiogenesis of Injected Diced Cartilage.

ABSTRACT:

Objectives

This study explored the effect of adipose-derived stromal vascular fractions (SVFs) on angiogenesis in injected autologous diced cartilage.

Methods

Stromal vascular fractions were extracted by enzymatic digestion. Cartilage grafts were harvested from 1 side of the auricular cartilage of New Zealand rabbit and then diced to a size of 1.0 mm3. The grafts were divided into 2 groups. The control group was diced cartilage mixed with culture medium, and the experimental group was diced cartilage mixed with SVFs. The 2 groups of composite grafts were subcutaneously implanted on both sides of the back of each rabbit. After 4, 12 and 24 weeks, the tissue structure, number of blood vessels, and angiogenic factors in the grafts were observed.

Results

The SVFs conforme

SUBMITTER: Yin H 

PROVIDER: S-EPMC8865209 | biostudies-literature | 2022 Mar-Apr 01

REPOSITORIES: biostudies-literature