Timing of antimicrobial prophylaxis for cesarean section is critical for gut microbiome development in term born infants.

ABSTRACT: Animal models imply that the perinatal exposure to antibiotics has a substantial impact on microbiome establishment of the offspring. We aimed to evaluate the effect of timing of antimicrobial prophylaxis for cesarean section before versus after cord clamping on gut microbiome composition of term born infants. We performed an exploratory, single center randomized controlled clinical trial. We included forty pregnant women with elective cesarean section at term. The intervention group received single dose intravenous cefuroxime after cord clamping (n = 19), the control group single dose intravenous cefuroxime 30 minutes before skin incision (n = 21). The primary endpoint was microbiome signature of infants and metabolic prediction in the first days of life as determined in meconium samples

SUBMITTER: Bossung V 

PROVIDER: S-EPMC8865290 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature