LPIN1 Is a Regulatory Factor Associated With Immune Response and Inflammation in Sepsis.

ABSTRACT:

Objectives

Sepsis is a clinical disease that is typically treated in the intensive care unit, and the complex pathophysiology under this disease has not been thoroughly understood. While ferroptosis is involved in inflammation and infection, its effect in sepsis is still unknown. The study aimed to identify ferroptosis-related genes in sepsis, providing translational potential therapeutic targets.

Methods

The dataset GSE65682 was used to download the sample source from the Gene Expression Omnibus (GEO) database. Consensus weighted gene co-expression network analysis (WGCNA) was performed to find suspected modules of sepsis. The differentially expressed genes (DEGs) most significantly associated with mortality were intersected with those altered by lipopolysaccharide (LPS) tr

SUBMITTER: Dai W 

PROVIDER: S-EPMC8865371 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature