Mammalian Orthoreovirus Reassortment Proceeds with Little Constraint on Segment Mixing.

ABSTRACT: Segmentation of viral genomes provides the potential for genetic exchange within coinfected cells. However, for this potential to be realized, coinfecting genomes must mix during the viral life cycle. The efficiency of reassortment, in turn, dictates its potential to drive evolution. The opportunity for mixing within coinfected cells may vary greatly across virus families, such that the evolutionary implications of genome segmentation differ as a result of core features of the viral life cycle. To investigate the relationship between viral replication compartments and genetic exchange, we quantified reassortment in mammalian orthoreovirus (reovirus). Reoviruses carry a 10-segmented, double-stranded RNA genome, which is replicated within proteinaceous structures termed inclusion bodies. We

SUBMITTER: Hockman MR 

PROVIDER: S-EPMC8865455 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature