Rab1b-GBF1-ARF1 Secretory Pathway Axis Is Required for Birnavirus Replication.

ABSTRACT: Birnaviruses are members of the Birnaviridae family, responsible for major economic losses to poultry and aquaculture. The family is composed of nonenveloped viruses with a segmented double-stranded RNA (dsRNA) genome. Infectious bursal disease virus (IBDV), the prototypic family member, is the etiological agent of Gumboro disease, a highly contagious immunosuppressive disease in the poultry industry worldwide. We previously demonstrated that IBDV hijacks the endocytic pathway for establishing the viral replication complexes on endosomes associated with the Golgi complex (GC). Here, we report that IBDV reorganizes the GC to localize the endosome-associated replication complexes without affecting its secretory functionality. By analyzing crucial proteins involved in the secret

SUBMITTER: Gimenez MC 

PROVIDER: S-EPMC8865525 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature