Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis.

ABSTRACT: Rationale: Fibrotic hypersensitivity pneumonitis (fHP) is an interstitial lung disease caused by sensitization to an inhaled allergen. Objectives: To identify the molecular determinants associated with progression of fibrosis. Methods: Nine fHP explant lungs and six unused donor lungs (as controls) were systematically sampled (4 samples/lung). According to microcomputed tomography measures, fHP cores were clustered into mild, moderate, and severe fibrosis groups. Gene expression profiles were assessed using weighted gene co-expression network analysis, xCell, gene ontology, and structure enrichment analysis. Gene expression of the prevailing molecular traits was also compared with idiopathic pulmonary fibrosis (IPF). The explant lung findings were evaluated in separate

SUBMITTER: De Sadeleer LJ 

PROVIDER: S-EPMC8865586 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature