Correlation analysis of m6A-modified regulators with immune microenvironment infiltrating cells in lung adenocarcinoma.

ABSTRACT:

Object

Recent studies have demonstrated the epigenetic regulation of immune responses. However, the potential role of N6-methyladenosine methylation (m6A) in the tumor microenvironment (TME) remains unknown.

Method

In this study, the m6A modification patterns of LUAD samples were comprehensively evaluated by combining TCGA and GEO data, while these modification patterns were systematically linked to the characteristics of immune infiltrating cells in TME. The m6A score was constructed using the principal component analysis algorithm to quantify the m6A modification mode of a single tumor.

Result

There were three distinct patterns of m6A modification identified. The characteristics of TME cell infiltration in these three patterns were highly consistent with these three

SUBMITTER: Ye W 

PROVIDER: S-EPMC8865675 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature