Mouse models of Japanese encephalitis virus infection: A systematic review and meta-analysis using a meta-regression approach.

ABSTRACT:

Background

Japanese encephalitis (JE) virus (JEV) remains a leading cause of neurological infection across Asia. The high lethality of disease and absence of effective therapies mean that standardised animal models will be crucial in developing therapeutics. However, published mouse models are heterogeneous. We performed a systematic review, meta-analysis and meta-regression of published JEV mouse experiments to investigate the variation in model parameters, assess homogeneity and test the relationship of key variables against mortality.

Methodology/ principal findings

A PubMed search was performed up to August 2020. 1991 publications were identified, of which 127 met inclusion criteria, with data for 5026 individual mice across 487 experimental groups. Quality assessment wa

SUBMITTER: Bharucha T 

PROVIDER: S-EPMC8865681 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature