Evaluation of the genetic risk for COVID-19 outcomes in COPD and differences among worldwide populations.

ABSTRACT:

Background

Populations seem to respond differently to the global pandemic of severe acute respiratory syndrome coronavirus 2. Recent studies show individual variability in both susceptibility and clinical response to COVID-19 infection. People with chronic obstructive pulmonary disease (COPD) constitute one of COVID-19 risk groups, being already associated with a poor prognosis upon infection. This study aims contributing to unveil the underlying reasons for such prognosis in people with COPD and the variability in the response observed across worldwide populations, by looking at the genetic background as a possible answer to COVID-19 infection response heterogeneity.

Methods

SNPs already associated with susceptibility to COVID-19 infection (rs286914 and rs12329760) and seve

SUBMITTER: Marcalo R 

PROVIDER: S-EPMC8865687 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature