Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis.

ABSTRACT: Rationale: Performance of blood transcriptomic tuberculosis (TB) signatures in longitudinal studies and effects of TB-preventive therapy and coinfection with HIV or respiratory organisms on transcriptomic signatures has not been systematically studied. Objectives: We evaluated longitudinal kinetics of an 11-gene blood transcriptomic TB signature, RISK11, and effects of TB-preventive therapy (TPT) and respiratory organisms on RISK11 signature score, in HIV-uninfected and HIV-infected individuals. Methods: RISK11 was measured in a longitudinal study of RISK11-guided TPT in HIV-uninfected adults, a cross-sectional respiratory organisms cohort, or a longitudinal study in people living with HIV (PLHIV). HIV-uninfected RISK11⁺ participants were randomized to TPT o

SUBMITTER: Mulenga H 

PROVIDER: S-EPMC8865716 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature