Blood metabolites predicting mild cognitive impairment in the study of Latinos-investigation of neurocognitive aging (HCHS/SOL).

ABSTRACT:

Introduction

Blood metabolomics-based biomarkers may be useful to predict measures of neurocognitive aging.

Methods

We tested the association between 707 blood metabolites measured in 1451 participants from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), with mild cognitive impairment (MCI) and global cognitive change assessed 7 years later. We further used Lasso penalized regression to construct a metabolomics risk score (MRS) that predicts MCI, potentially identifying a different set of metabolites than those discovered in individual-metabolite analysis.

Results

We identified 20 metabolites predicting prevalent MCI and/or global cognitive change. Six of them were novel and 14 were previously reported as associated with neurocognitive aging outcomes.

SUBMITTER: He S 

PROVIDER: S-EPMC8865745 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature