Efficient oral insulin delivery enabled by transferrin-coated acid-resistant metal-organic framework nanoparticles.

ABSTRACT: Oral protein delivery is considered a cutting-edge technology to improve patients' quality of life, offering superior patient compliance and convenience compared with injections. However, oral protein formulation has stagnated because of the instability and inefficient penetration of protein in the gastrointestinal tract. Here, we used acid-resistant metal-organic framework nanoparticles (UiO-68-NH₂) to encapsulate sufficient insulin and decorated the exterior with targeting proteins (transferrin) to realize highly efficient oral insulin delivery. The UiO-68-NH₂ nanocarrier with proper pore size achieved high insulin loading while protecting insulin from acid and enzymatic degradation. Through receptor-mediated transcellular pathway, the transferrin-coated nanoparticl

SUBMITTER: Zou JJ 

PROVIDER: S-EPMC8865763 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature