Oxidative stress-induced endothelial dysfunction and decreased vascular nitric oxide in COVID-19 patients.

ABSTRACT:

Background

SARS-CoV-2 targets endothelial cells through the angiotensin-converting enzyme 2 receptor. The resulting endothelial injury induces widespread thrombosis and microangiopathy. Nevertheless, early specific markers of endothelial dysfunction and vascular redox status in COVID-19 patients are currently missing.

Methods

Observational study including ICU and non-ICU adult COVID-19 patients admitted in hospital for acute respiratory failure, compared with control subjects matched for cardiovascular risk factors similar to ICU COVID-19 patients, and ICU septic shock patients unrelated to COVID-19.

Findings

Early SARS-CoV-2 infection was associated with an imbalance between an exacerbated oxidative stress (plasma peroxides levels in ICU patients vs. controls: 1456.0

SUBMITTER: Montiel V 

PROVIDER: S-EPMC8865837 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature