Does a gluten-free diet lead to better glycemic control in children with type 1 diabetes? Results from a feasibility study and recommendations for future trials.

ABSTRACT:

Background

Increasing evidence suggests a link between type 1 diabetes (T1D) and intake of gluten, but no controlled trials have examined whether a gluten-free diet (GFD) has positive effects on glycemic control in children with T1D.

Methods

We conducted a non-randomized feasibility study. Twenty-three children with newly diagnosed T1D were included and either followed a GFD (n = 14) or a normal diet (n = 9) for 12 months. Effects of diet on glycemic control were examined by measuring insulin production (c-peptide), hemoglobine A1c (HbA1c) and insulin dose adjusted A1c (IDAA1c). Degree of adherence to the GFD and effects on quality of life were also examined.

Results

Children on a GFD showed a statistically significantly lower HbA1c at six months (P = 0.042) compared

SUBMITTER: Soderstrom H 

PROVIDER: S-EPMC8866053 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature