Association of cognitive performance with clinical staging in schizophrenia spectrum disorders: a prospective 6-year follow-up study.

ABSTRACT:

Background

Clinical staging has been developed to capture the large heterogeneity in schizophrenia spectrum disorders. Including cognitive performance in the staging model may improve its clinical validity. Moreover, cognitive functioning could predict transition across stages. However, current evidence of the association between cognition and clinical staging is inconsistent. Therefore, we aim to assess whether cognitive parameters are associated with clinical stages in a large sample of patients with schizophrenia spectrum disorders and to identify cognitive markers at baseline that are associated with stage-transition at three and six-year follow-up.

Methods

We applied the staging model of Fusar-Poli et al. (2017) in 927 patients with non-affective psychotic disorders, as

SUBMITTER: Berendsen S 

PROVIDER: S-EPMC8866148 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature