Survivin is essential for thermogenic program and metabolic homeostasis in mice.

ABSTRACT:

Objective

Survivin is a member of the inhibitor of apoptosis family. Our previous study showed that survivin expression could be strongly induced by long-term, high-fat diet (HFD) exposure in vivo. It could also be induced by insulin through the PI3K/mTOR signaling pathway in vitro. Therefore, we hypothesized that under certain conditions, survivin expression might be required for adipocyte function. In the current study, we aim to further investigate the regulation of survivin expression in mature adipocytes upon various nutritional stimuli and the role of survivin using adipocyte-specific survivin knockout (SKO) mice.

Methods

SKO mice were obtained by crossing survivin^flox/flox mice with Adiponectin-Cre^+/- mice. The overall metabolic phenotype was obs

SUBMITTER: Alimujiang M 

PROVIDER: S-EPMC8866150 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature