Genetic variation in endocannabinoid signaling is associated with differential network-level functional connectivity in youth.

ABSTRACT: The endocannabinoid system is an important regulator of emotional responses such as fear, and a number of studies have implicated endocannabinoid signaling in anxiety. The fatty acid amide hydrolase (FAAH) C385A polymorphism, which is associated with enhanced endocannabinoid signaling in the brain, has been identified across species as a potential protective factor from anxiety. In particular, adults with the variant FAAH 385A allele have greater fronto-amygdala connectivity and lower anxiety symptoms. Whether broader network-level differences in connectivity exist, and when during development this neural phenotype emerges, remains unknown and represents an important next step in understanding how the FAAH C385A polymorphism impacts neurodevelopment and risk for anxiety disorders. Here, we

SUBMITTER: Sisk LM 

PROVIDER: S-EPMC8866205 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature