Insulin sensitivity and kinetics in African American and White people with obesity: Insights from different study protocols.

ABSTRACT:

Objective

Studies that used an intravenous glucose tolerance test (IVGTT) have suggested that race is an important modulator of insulin sensitivity, β-cell function, and insulin clearance. However, the validity of the IVGTT has been challenged.

Methods

This study assessed insulin sensitivity and insulin kinetics in non-Hispanic White (NHW, n = 29) and African American (AA, n = 14) people with obesity by using a hyperinsulinemic-euglycemic pancreatic clamp with glucose tracer infusion, an oral glucose tolerance test (OGTT), and an IVGTT.

Results

Hepatic insulin sensitivity was better in AA participants than in NHW participants. Muscle insulin sensitivity, insulin secretion in relation to plasma glucose during the OGTT, and insulin clearance during basal conditions duri

SUBMITTER: Koh HE 

PROVIDER: S-EPMC8866210 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature