Role of aurora kinase B in regulating resistance to paclitaxel in breast cancer cells.

ABSTRACT: Aurora kinase B (AURKB) is a type of functional kinase with primary functions of participating in cell mitosis, which has been identified to be involved in the occurrence and development of malignant tumors strongly. However, it still remains a controversial with respect to the relationship between the phosphorylation level of AURKB and its function. In our initial research, there was no significant difference in the relative content of AURKB protein between drug-resistant breast cancer cells and wild-type cells; however, its phosphorylation level in drug-resistant cells was significantly higher than that in wild-type cells. Subsequent cell and animal experiments both confirmed the positive correlation between AURKB phosphorylation and drug resistance. Furthermore, PRKCE in the upstream wa

SUBMITTER: Liu M 

PROVIDER: S-EPMC8866333 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature