Reproducible neuroimaging features for diagnosis of autism spectrum disorder with machine learning.

ABSTRACT: Autism spectrum disorder (ASD) is the fourth most common neurodevelopmental disorder, with a prevalence of 1 in 160 children. Accurate diagnosis relies on experts, but such individuals are scarce. This has led to increasing interest in the development of machine learning (ML) models that can integrate neuroimaging features from functional and structural MRI (fMRI and sMRI) to help reveal central nervous system alterations characteristic of ASD. We optimized and compared the performance of 12 of the most popular and powerful ML models. Each was separately trained using 15 different combinations of fMRI and sMRI features and optimized with an unbiased model search. Deep learning models predicted ASD with the highest diagnostic accuracy and generalized well to other MRI datasets. Our model ac

SUBMITTER: Mellema CJ 

PROVIDER: S-EPMC8866395 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature