Recent advances in smart stimuli-responsive biomaterials for bone therapeutics and regeneration.

ABSTRACT: Bone defects combined with tumors, infections, or other bone diseases are challenging in clinical practice. Autologous and allogeneic grafts are two main traditional remedies, but they can cause a series of complications. To address this problem, researchers have constructed various implantable biomaterials. However, the original pathological microenvironment of bone defects, such as residual tumors, severe infection, or other bone diseases, could further affect bone regeneration. Thus, the rational design of versatile biomaterials with integrated bone therapy and regeneration functions is in great demand. Many strategies have been applied to fabricate smart stimuli-responsive materials for bone therapy and regeneration, with stimuli related to external physical triggers or endogenous dise

SUBMITTER: Wei H 

PROVIDER: S-EPMC8866424 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature