Interventional neurorehabilitation for promoting functional recovery post-craniotomy: a proof-of-concept.

ABSTRACT: The human brain is a highly plastic 'complex' network-it is highly resilient to damage and capable of self-reorganisation after a large perturbation. Clinically, neurological deficits secondary to iatrogenic injury have very few active treatments. New imaging and stimulation technologies, though, offer promising therapeutic avenues to accelerate post-operative recovery trajectories. In this study, we sought to establish the safety profile for 'interventional neurorehabilitation': connectome-based therapeutic brain stimulation to drive cortical reorganisation and promote functional recovery post-craniotomy. In n = 34 glioma patients who experienced post-operative motor or language deficits, we used connectomics to construct single-subject cortical networks. Based on their clinical and conne

SUBMITTER: Poologaindran A 

PROVIDER: S-EPMC8866464 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature