Linking path and filament persistence lengths of microtubules gliding over kinesin.

ABSTRACT: Microtubules and kinesin motor proteins are involved in intracellular transports in living cells. Such intracellular material transport systems can be reconstructed for utilisation in synthetic environments, and they are called molecular shuttles driven by kinesin motors. The performance of the molecular shuttles depends on the nature of their trajectories, which can be characterized by the path persistence length of microtubules. It has been theoretically predicted that the path persistence length should be equal to the filament persistence length of the microtubules, where the filament persistence length is a measure of microtubule flexural stiffness. However, previous experiments have shown that there is a significant discrepancy between the path and filament persistence lengths. Here,

SUBMITTER: Sweet M 

PROVIDER: S-EPMC8866476 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature