Healthcare microenvironments define multidrug-resistant organism persistence.

ABSTRACT:

Background

Multidrug-resistant organisms (MDROs) colonizing the healthcare environment have been shown to contribute to risk for healthcare-associated infections (HAIs), with adverse effects on patient morbidity and mortality. We sought to determine how bacterial contamination and persistent MDRO colonization of the healthcare environment are related to the position of patients and wastewater sites.

Methods

We performed a prospective cohort study, enrolling 51 hospital rooms at the time of admitting a patient with an eligible MDRO in the prior 30 days. We performed systematic sampling and MDRO culture of rooms, as well as 16S rRNA sequencing to define the environmental microbiome in a subset of samples.

Results

The probability of detecting resistant gram-negative orga

SUBMITTER: Kelly BJ 

PROVIDER: S-EPMC8866524 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature