Multi-Omics Profiling Specifies Involvement of Alternative Ribosomal Proteins in Response to Zinc Limitation in Mycobacterium smegmatis.

ABSTRACT: Zinc ion (Zn²⁺) is an essential micronutrient and a potent antioxidant. However, Zn²⁺ is often limited in the environment. Upon Zn²⁺ limitation, Mycolicibacterium (basonym: Mycobacterium) smegmatis (Msm) undergoes a morphogenesis, which relies on alternative ribosomal proteins (AltRPs); i.e., Zn²⁺-independent paralogues of Zn²⁺-dependent ribosomal proteins. However, the underlying physiological changes triggered by Zn²⁺ limitation and how AltRPs contribute to these changes were not known. In this study, we expand the knowledge of mechanisms utilized by Msm to endure Zn²⁺ limitation, by comparing the transcriptomes and proteomes of Zn²⁺-limited and Zn²⁺-replete M

SUBMITTER: Dow A 

PROVIDER: S-EPMC8866557 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature