Links Between N ⁶-Methyladenosine and Tumor Microenvironments in Colorectal Cancer.

ABSTRACT: N ⁶-methyladenosine (m⁶A) is a critical epigenetic modification for tumor malignancies, but its role in regulating the tumor microenvironments (TMEs) has not been fully studied. By integrating multiple data sets and multi-omics data, we comprehensively evaluated the m⁶A "writers," "erasers," and "readers" in colorectal cancer and their association with TME characteristics. The m⁶A regulator genes showed specific patterns in co-mutation, copy number variation, and expression. Based on the transcriptomic data of the m⁶A regulators and their correlated genes, two types of subtyping systems, m⁶A_regCluster and m⁶A_sigCluster, were developed. The clusters were distinct in pathways (metabolism

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8866562 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature