Screening and identification of potential inhibitor for visceral leishmaniasis (VL) through computational analysis.

ABSTRACT:

Aim

The aim of this investigation is to detect potential inhibitor for visceral leishmaniasis through computational analysis.

Background

Leishmaniasis is categorized as a vector born pathogenic infection prevalent in tropical, subtropical, and in Mediterranean zones spread by intra-macrophage protozoa. The clinical syndrome of leishmaniasis is divided into the following type's namely cutaneous leishmaniasis, mucocutaneous leishmaniasis, visceral leishmaniasis, and dermal leishmaniasis. Trypanothione synthetase is a key enzyme involving in glutathione biosynthesis as well as hydrolysis. Trypanothione is one of the promising drug targets for parasites. Parasites are inimitable with concern to their dependence on trypanothione to regulate intracellular thiol-redox balance in fi

SUBMITTER: Shaslinah N 

PROVIDER: S-EPMC8866605 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature