Proteomic Signatures of Antimicrobial Resistance in Yersinia pestis and Francisella tularensis.

ABSTRACT: Antimicrobial resistance (AMR) is a well-recognized, widespread, and growing issue of concern. With increasing incidence of AMR, the ability to respond quickly to infection with or exposure to an AMR pathogen is critical. Approaches that could accurately and more quickly identify whether a pathogen is AMR also are needed to more rapidly respond to existing and emerging biological threats. We examined proteins associated with paired AMR and antimicrobial susceptible (AMS) strains of Yersinia pestis and Francisella tularensis, causative agents of the diseases plague and tularemia, respectively, to identify whether potential existed to use proteins as signatures of AMR. We found that protein expression was significantly impacted by AMR status. Antimicrobial resistance-conferring

SUBMITTER: Deatherage Kaiser BL 

PROVIDER: S-EPMC8866660 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature