Biodistribution and Dosimetry Evaluation for a Novel Tau Tracer [¹⁸F]-S16 in Healthy Volunteers and Its Application in Assessment of Tau Pathology in Alzheimer's Disease.

ABSTRACT: Background: The goal of this study was to report a fully automated radiosynthetic procedure of a novel tau tracer [¹⁸F]-S16 and its safety, biodistribution, and dosimetry in healthy volunteers as well as the potential utility of [¹⁸F]-S16 positron emission tomography (PET) in Alzheimer's disease (AD). Methods: The automated radiosynthesis of [¹⁸F]-S16 was performed on a GE Tracerlab FX2 N module. For the biodistribution and dosimetry study, healthy volunteers underwent a series of PET scans acquired at 10, 60, 120, and 240 min post-injection. The biodistribution and safety were assessed. For the AD study, both AD and healthy controls (HCs) underwent dynamic [¹⁸F]-S16 and static [¹⁸F]-FDG PET imaging. [¹⁸F]-S16

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8866701 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature