inlF Enhances Listeria monocytogenes Early-Stage Infection by Inhibiting the Inflammatory Response.

ABSTRACT: The internalin family proteins, which carry the leucine repeat region structural motif, play diverse roles in Listeria monocytogenes (Lm) infection and pathogenesis. Although Internalin F, encoded by inlF, was identified more than 20 years ago, its role in the Lm anti-inflammatory response remains unknown. Lm serotype 4b isolates are associated with the majority of listeriosis outbreaks, but the function of InlF in these strains is not fully understood. In this study, we aimed to elucidate the role of inlF in modulating the inflammatory response and pathogenesis of the 4b strain Lm NTSN. Strikingly, although inlF was highly expressed at the transcriptional level during infection of five non-phagocytic cell types, it was not involved in adherence or invasi

SUBMITTER: Ling Z 

PROVIDER: S-EPMC8866704 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature