Cohesin-Mediated Chromatin Interactions and Autoimmunity.

ABSTRACT: Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-binding factor, it ensures insulator activity to organize enhancers and promoters within regulatory chromatin. Homozygous mutations and dysfunction of individual cohesin proteins are embryonically lethal in humans and mice, which limits in vivo research work to embryonic stem cells and progenitors. Conditional alleles of cohesin complex proteins have been generated to investigate their functional roles in greater detail at later developmental stages. Thus, genome regulation enabled by action of cohesin proteins is potentially crucia

SUBMITTER: Chandrasekaran V 

PROVIDER: S-EPMC8866859 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature