Hydrogen Sulfide Promotes Thyroid Hormone Synthesis and Secretion by Upregulating Sirtuin-1.

ABSTRACT: Objective: One mechanism of hypothyroidism involves the disruption of thyroid hormone synthesis and secretion by thyrocytes. Hydrogen sulfide (H₂S), as a gas signaling molecule, participates in many physiopathologic processes by upregulating sirtuin-1 (SIRT1). The aim of the current study was to explore whether H₂S promotes the synthesis and secretion of thyroid hormones by upregulating SIRT1. Methods: Real-time PCR and immunohistochemistry were used to detect the mRNA and protein expression of H₂S-generating enzymes in normal human thyroid tissues. Serum H₂S concentrations from hypothyroid patients (n = 32) and euthyroid participants (n = 41) were detected by H₂S-selective sensors. Thirty-one Sprague-Dawley

SUBMITTER: Zhao X 

PROVIDER: S-EPMC8866871 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature