Human Umbilical Cord Blood-Derived CD133⁺CD34⁺ Cells Protect Retinal Endothelial Cells and Ganglion Cells in X-Irradiated Rats through Angioprotective and Neurotrophic Factors.

ABSTRACT: Radiation retinopathy (RR) is a common complication following radiation therapy of globe, head, and neck malignancies, and is characterized by microangiopathy, neuroretinopathy, and the irreversible loss of visual function. To date, there is no effective treatment for RR. Stem cells have been clinically used to treat retinal degeneration. CD133⁺CD34⁺ cells from human umbilical cord blood (hUCB-CD133⁺CD34⁺ cells), a subpopulation of hematopoietic stem cells, were applied to determine their protective efficacy on irradiated rat retinas. After X-ray irradiation on the retinas, rats were intravitreally injected with hUCB-CD133⁺CD34⁺ cells. Transplantation of hUCB-CD133⁺CD34⁺ cells preve

SUBMITTER: Chen S 

PROVIDER: S-EPMC8866877 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature